Animal & Dairy Science: Personnel
Clifton A. Baile
Distinguished Professor and Georgia Research Alliance Eminent Scholar in Agricultural Biotechnology
B.S., Central Missouri State College
Ph.D., University of Missouri
M.A., (Honorary) University of Pennsylvania
Edgar L. Rhodes Center for ADS
University of Georgia
Athens, GA 30602-2771
Phone: 706/542-4094
Fax: 706/542-7925
Email: cbaile@uga.edu
Web site: http://www.arches.uga.edu/~cbaile/
Description of Research Interests
Our laboratory has broad interests in the molecular basis of energy balance regulation and growth. Our research includes various aspects of the control of feeding behavior and energy balance regulation by the central nervous system and adipose tissue. The roles of leptin and growth hormone in these functions are of particular interest. We are also investigating the roles of natural compounds in adipogenesis, lipolysis and adipocyte apoptosis. Biotechnology tools, including the development of transgenic animals and a variety of genomic and proteomic technologies, are utilized to study the molecular basis of these systems of animal physiology.
We have coordinated the Georgia Research Alliance's program in Agricultural Biotechnology at the University of Georgia. This program has dual goals of conducting leading-edge research and seeding start-up companies to commercialize animal and plant biotechnology in Georgia. State of the art equipment, in conjunction with cutting-edge technologies such as genomics, bioinformatics, vector construction, both high through-put screening and genotyping, and transgenesis are available.
Selected Recent Publications
Kim, Hye-Kyeong, Cass Nelson-Dooley, , Mary Anne Della-Fera, Jeong-Yeh Yang, Wei Zhang, Diane L Hartzell, Mark W Hamrick, and Clifton A. Baile. Genistein Decreases Food Intake, Body Weight and Fat Pad Weight and Causes Adipose Tissue Apoptosis in Ovariectomized Female Mice. Journal of Nutrition 136:409-414, 2006.
Nelson-Dooley, C., M.A. Della-Fera, M. Hamrick and C.A. Baile. Novel Treatments for Obesity and Osteoporosis: Targeting Apoptotic Pathways in Adipocytes. Current Medicinal Chemistry 12:2215-2225, 2005.
Hamrick, Mark W., Mary Anne Della-Fera, Yang-Ho Choi, Catherine Pennington, Diane Hartzell, and Clifton A. Baile. Leptin Treatment Induces Loss of Bone Marrow Adipocytes & Increases Bone Formation in Leptin-Deficient ob/ob Mice. J Bone Miner Res. 20:994-1001, 2005.
Della-Fera, Mary Anne, Yang-Ho Choi, Diane L. Hartzell, Jiuhua Duan, Mark Hamrick and Clifton A. Baile. Sensitivity of ob/ob Mice to Leptin-Induced Adipose Tissue Apoptosis. Obesity Research. 13:1540-1547, 2005.
Lin, Ji, Mary Anne Della-Fera1 and Clifton A. Baile. Green tea polyphenol EGCG inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes. Obesity Research. 13: 982-990, 2005.
Della-Fera, Mary Anne and Clifton A. Baile. Roles for Melanocortins and Leptin in Adipose Tissue Apoptosis and Fat Deposition. Peptides 26: 1782-1787, 2005.
Choi, Yang-Ho, Mary Anne Della-Fera, ChangLong Li, Diane L. Hartzell, Dianne E. Little, Michael J. Kuhar and Clifton A. Baile. CART peptide: Central mediator of leptin-induced adipose tissue apoptosis? Regulatory Peptides 121: 155-162, 2004.
Duff, Emily, ChangLong Li, Diane L. Hartzell, Yang-Ho Choi, Mary Anne Della-Fera and Clifton A. Baile. Ciliary Neurotrophic Factor Injected Icv Induces Adipose Tissue Apoptosis in Rats, Apoptosis 9:629-634, 2004.
Lin, Ji, Karen Page, Mary Anne Della-Fera and Clifton A. Baile. Evaluation of Adipocyte Apoptosis by Laser Scanning Cytometry. International Journal of Obesity 28:1535-1540, 2004.
Baile, Clifton A. and Mary Anne Della-Fera. Myostatin: Physiology and Applications. Encyclopedia of Animal Science. DOI:10.1081/E-EAS and Encyclopedia of Animal Science (11/10/2004) P661-663, 2004.
Hargrave, Kimberly M., Brett J. Meyer, Changlong Li, Michael J. Azain, Clifton A. Baile, Jess L. Miner. Influence of Conjugated Linoleic Acid and Fat Source on Body Fat and Apoptosis in Mice. Obesity Research 12, 2004.
Page, Karen A., Diane L. Hartzell, Changlong Li, Alisha L. Westby, Mary Anne Della-Fera, Michael J. Azain, Timothy D. Pringle and Clifton A. Baile. Effects of ?-adrenergic Receptor Agonists on Adipose Tissue Growth and Apoptosis in Mice. Domestic Animal Endocrinology 26:23-31, 2004.
Gullicksen, P. S., R. G. Dean, C. D. Berdanier, and C. A. Baile. Detection of DNA fragmentation, the apoptotic proteins, and the quantification of uncoupling protein expression by real-time RT-PCR in adipose tissue. Journal of Biochemical & Biophysical Methods; 58:1-13, 2004.
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